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A sugar substitute is a food additive which duplicates the effect of sugar in taste, but often with less food energy. In Commonwealth English, sugar substitutes are often referred to as "sweeteners" (to the exclusion of sugar).
An important class of sugar substitutes are known as high intensity sweeteners.
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Acesulfame Potassium
Popular products containing acesulfame K include Diet Rite Cola, Pepsi One/Pepsi Max, Coca-Cola Zero, Diet Coke with Splenda, Trident gum, and sugarfree Jell-O. In diet sodas it is almost always used in conjunction with another sweetener, such as aspartame or sucralose.
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Aspartame
Searle first sought FDA approval of aspartame in dry foods and as a table-top sweetener in March 1973. FDA approved that petition in July 1974, but challenges over the substance's safety and the validity of the company's data kept aspartame from being marketed. To resolve the safety issues, the contesting parties agreed to put the matter in the hands of a scientific board of inquiry. Before the board could meet, however, FDA had to resolve the challenge to the validity of various studies conducted for Searle. Their validity was affirmed by an outside panel of pathologists in a December 1978 report to FDA.
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Cyclamate
Cyclamate was introduced into beverages and foods in the early 1950's, and it dominated the artificial sweetener market through most of the 1960s. But in 1968, the National Academy of Sciences (NAS) told FDA that, although consumption of reasonable quantities of cyclamate probably posed no hazard to humans, additional studies were needed to resolve various aspects of cyclamate's safety.
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Neotame - NutraSweet
Neotame is an artificial sweetener made by NutraSweet. It is derived from and similar in structure to aspartame. However, Neotame is heat stable, much more potent, and of no danger to those suffering from phenylketonuria, as it does not metabolize into phenylalanine.
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Saccharin
What puzzles many people is how a food additive may suddenly be branded as unsafe after many years of seemingly safe use. The case of saccharin is a good example of how the shifting requirements of the law, the progress of science, and new trends in food uses can change a substance's status from "safe" to "unsafe."
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Sucralose - Splenda
Sucralose is a non-caloric sweetener, also known by the trade name SPLENDA. In the European Union it is also known under the E number E955. It is 500–600 times as sweet as sucrose, making it roughly twice as sweet as saccharin and four times as sweet as aspartame.
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