Cyclamate
Cyclamate was introduced into beverages and foods in the early 1950's, and it dominated the artificial sweetener market through most of the 1960s. But in 1968, the National Academy of Sciences (NAS) told FDA that, although consumption of reasonable quantities of cyclamate probably posed no hazard to humans, additional studies were needed to resolve various aspects of cyclamate's safety.
Acesulfame Potassium
Popular products containing acesulfame K include Diet Rite Cola, Pepsi One/Pepsi Max, Coca-Cola Zero, Diet Coke with Splenda, Trident gum, and sugarfree Jell-O. In diet sodas it is almost always used in conjunction with another sweetener, such as aspartame or sucralose.